Semaglutide, the active ingredient used in medications like Ozempic and Wegovy, is used to manage type 2 diabetes and promote weight loss. Like with any medication, it is important to understand the possible side effects and evaluate potential solutions to lessen their severity. Throughout this guide, we will address your concerns regarding the common, long-term and rare side effects of semaglutide and provide solutions to ease your symptoms.
What Is Semaglutide?
Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used to control blood sugar levels in adults with type 2 diabetes. It’s also prescribed to adults for weight management in overweight or obese patients.
What Is Compounded Semaglutide?
Due to the nationwide drug shortage, medications like Ozempic and Wegovy have become increasingly difficult to obtain. However, compounded semaglutide from 503B outsourcing facilities offers a viable alternative for patients, as these facilities can produce medications that have been added to the drug shortage list.
How Does Semaglutide Work?
Glucagon-like peptide-1 (GLP-1) is a gut-produced hormone essential for glucose regulation and metabolism, aiding in the maintenance of stable blood sugar levels. By mimicking GLP-1, semaglutide increases insulin release to manage blood glucose and reduce appetite by signaling to the nervous system a feeling of fullness. Additionally, semaglutide suppresses glucagon secretion, thereby reducing glucose production by the liver and slowing gastric emptying, which helps to lower the rate at which glucose is absorbed into the bloodstream.
Managing Side Effects
Before diving into the specific side effects, let’s first discuss proactive steps you can take to manage and mitigate these potential issues. Semaglutide is most effective when used in conjunction with a healthy lifestyle, including a balanced diet and regular exercise. Adopting these habits can enhance the drug’s benefits while alleviating its side effects.
- Opt for nutrient-dense foods: Since semaglutide often reduces appetite, it’s important to include nutrient-dense foods to ensure your body gets the essential nutrients it needs to function properly. Opt for foods such as fruits, vegetables, lean proteins and whole grains while limiting your consumption of fried foods, spicy foods, fatty foods and foods and beverages with an excess amount of sugar.
- Stay well-hydrated: Staying hydrated lowers your risk of experiencing some of the more severe side effects, such as kidney issues. It’s also advisable to limit your caffeine intake since caffeine tends to cause dehydration.
- Consult your doctor before increasing dosage: Monitor how your body responds to each change and report any side effects to your medical provider.
- Attend all scheduled appointments: Regular monitoring allows for early detection of potential problems.
Common Side Effects of Semaglutide
As with any medication, semaglutide may induce various side effects. These are most commonly mild to moderate and often involve the gastrointestinal system. Recognizing these side effects can help patients and healthcare providers effectively manage treatment options and establish realistic expectations.
Gastrointestinal Issues
Some of the most common side effects are:
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Abdominal pain
Nausea is particularly common, especially when beginning treatment or increasing dosage. Typically, these side effects subside within a few days or a couple of weeks. If they persist or worsen, please consult with your healthcare provider.
Metabolic Effects
- Hypoglycemia (low blood sugar), particularly when used with other diabetes medications
- Weight loss
Other Common Side Effects
- Headache
- Fatigue
- Dizziness
Serious Side Effects of Semaglutide
Although rare, certain side effects may occur that may need immediate medical attention.
Pancreatitis
Watch out for symptoms such as:
- Severe abdominal pain
- Nausea
- Vomiting
If you experience any of these, contact your healthcare professional immediately.
Kidney Problems
In some patients, semaglutide may cause kidney issues. This is more likely to occur if you have experienced vomiting or diarrhea, which can lead to dehydration.
To help alleviate these risks, it is advised to stay hydrated. Be alert for signs such as:
- Swelling of your ankles, feet or legs
- Changes in urination frequency or color.
Allergic Reactions
Although rare, severe allergic reactions can occur. Symptoms may include:
- Rash
- Itching
- Swelling
- Rapid heartbeat
- Difficulty breathing
If you had an allergic reaction to medication in the same class, then it is likely you are also allergic to semaglutide. Seek emergency medical care immediately if you experience any of these symptoms.
Rare Side Effects
Cardiovascular Issues
In some patients, semaglutide may impact certain cardiovascular functions, such as:
- Changes in heart rate (either increased or decreased)
- Fluctuations in blood pressure
- Palpitations or irregular heartbeat
While you are taking semaglutide, it is important to regularly monitor your blood pressure and heart rate.
If you have a history of heart disease or are at high risk of cardiovascular issues, your doctor may advise more frequent monitoring while you are taking semaglutide.
Gallbladder Problems
In rare cases, semaglutide has been associated with gallbladder issues, such as
gallstones. Patients should be aware of the following symptoms:
- Severe abdominal pain, especially near the upper right abdomen
- Fever or chills
- Jaundice (yellowing of the skin or eyes)
- Nausea or vomiting
- Clay-colored stool
If you have experienced any of these symptoms, seek medical attention promptly. Your doctor may need to perform tests to evaluate your gallbladder function.
When to Seek Medical Attention
If you experience any of the following symptoms, contact your healthcare provider immediately:
- Severe or persistent vomiting or diarrhea
- Signs of pancreatitis or gallbladder problems
- Symptoms of an allergic reaction
- Any other concerning or severe side effects
Trust Olympia Pharmaceuticals for Safe and Effective Compounded Semaglutide
Although the safety of diabetic medications like semaglutide is sometimes questioned, it’s important to note that semaglutide has been extensively studied and shown to be effective and generally well-tolerated.
Olympia Pharmaceuticals is working to alleviate the diabetic medication shortage and expand patient access by offering compounded semaglutide. Olympia’s Semaglutide is compounded at our 503B facility under strict cGMP guidelines and federal regulations. It is available for purchase through both its 503B and 503A facilities.
Discover the difference with Olympia Pharmaceuticals for your compounded semaglutide needs. Whether you’re a healthcare provider seeking reliable compounded medications or a patient looking for effective treatment, trust Olympia Pharmaceuticals for excellence in pharmaceutical care. Learn more about our GLP-1 agonist options.